Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22409346 | 1.00 | ARG1 (0.39) | ARG1CHRM5ADRA2CGAA | |
| Hydrochloric Acid SCHEMBL8563521 | 0.98 | ARG1 (0.38) | ARG1CHRM5ADRA2CGAA | |
| SCHEMBL8557435 | 0.89 | GAA (0.42) | ARG1ADRA2CGAA | |
| SCHEMBL22409315 | 0.75 | ARG1 (0.39) | ARG1 | |
| SCHEMBL22409313 | 0.75 | ARG1 (0.39) | ARG1 | |
| SCHEMBL255277 | 0.71 | HTR1A (0.45) | ARG1CHRM5ADRA2C | |
| SCHEMBL488433 | 0.71 | HTR1A (0.45) | ARG1CHRM5ADRA2C | |
| SCHEMBL488775 | 0.71 | HTR1A (0.45) | ARG1CHRM5ADRA2C | |
| SCHEMBL16716869 | 0.71 | HTR1A (0.45) | ARG1CHRM5ADRA2C | |
| SCHEMBL18579090 | 0.70 | CHRM5 (0.46) | CHRM5ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |
| US-10898504-B2 | Substituted nucleoside analogues for use as PRMT5 inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2021-01-26 | — | — | US | disclosed |
| US-20200289539-A1 | NOVEL SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-09-17 | — | — | US | disclosed |
| US-5756730-A | Process for preparing analgesic compounds | SANKYO COMPANY, LIMITED (JP) | 1998-05-26 | — | — | US | disclosed |
| US-5656758-A | AMIDATION OF AN AMINE-CONTAINING THIOMORPHOLINE OR PIPERAZINE COMPOUND | SANKYO COMPANY, LIMITED (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5512567-A | KAPPA-RECEPTOR AGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-04-30 | — | — | US | disclosed |
| US-5270327-A | Piperidine derivatives | SANKYO COMPANY, LIMITED (JP) | 1993-12-14 | — | — | US | disclosed |
| EP-0356247-B1 | ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES | Sankyo Company Limited (JP) | 1993-03-17 | — | — | EP | disclosed |
| US-5021413-A | Analgesic thiomorpholins their preparation, and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1991-06-04 | — | — | US | disclosed |
| US-4948719-A | NONFOGGING, NONDELAMINATING | FUJI PHOTO FILM CO., LTD. (JP) | 1990-08-14 | — | — | US | disclosed |
| US-4923863-A | ANALGESICS, ANTIISCHEMICS | GLAXO GROUP LIMITED (GB) | 1990-05-08 | — | — | US | disclosed |
| EP-0356247-A1 | Analgesic carboxylic acid amide derivatives | Sankyo Company Limited (JP) | 1990-02-28 | — | — | EP | disclosed |
| EP-0346115-A1 | Morpholine derivatives | GLAXO GROUP LIMITED (GB) | 1989-12-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200289539-A1 | NOVEL SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT3 | ARG1 65/4885CHRM5 1196/4885ADRA2C 3612/4885 |
| US-10898504-B2 | Substituted nucleoside analogues for use as PRMT5 inhibitors | PRMT5, PRMT1, PRMT3 | ARG1 105/4885CHRM5 976/4885ADRA2C 3734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.