Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 7/20 | 0.48 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | CTRC | Q99895 | 2/20 | 0.44 |
| ▸ | GLB1 | P16278 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 4/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561560 | 0.90 | CTSD (0.55) | CTSDKDRBRAFKITFLT3 | |
| SCHEMBL8563315 | 0.84 | KDR (0.51) | CTSDKDRBRAFKITFLT3 | |
| SCHEMBL8561563 | 0.74 | CTSD (0.56) | CTSDKDRBRAFKITFLT3 | |
| SCHEMBL8561501 | 0.73 | BRAF (0.47) | KDRBRAFKITFLT3 | |
| SCHEMBL8559828 | 0.73 | CTSD (0.55) | CTSDKDRBRAFKITFLT3 | |
| SCHEMBL28942660 | 0.73 | CTSD (0.51) | CTSDKDRMEN1MAPTKMT2A | |
| SCHEMBL29612906 | 0.73 | CTSD (0.51) | CTSDKDRMEN1MAPTKMT2A | |
| SCHEMBL29612951 | 0.71 | CTSD (0.53) | CTSDCTRCGLB1MEN1NPC1 | |
| SCHEMBL28760749 | 0.71 | CTSD (0.53) | CTSDCTRCGLB1MEN1NPC1 | |
| SCHEMBL10838242 | 0.71 | CTSD (0.65) | CTSDMEN1NPC1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |