Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 6/20 | 0.45 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559829 | 0.84 | CTSD (0.53) | CTSDKDRHSPD1PTPN2PTPN1 | |
| SCHEMBL8561560 | 0.80 | CTSD (0.55) | CTSDKDRHSPD1HSPE1BRAF | |
| SCHEMBL8561501 | 0.80 | BRAF (0.47) | KDRBRAFKITFLT3GRM4 | |
| SCHEMBL7947680 | 0.74 | IL2 (0.54) | KDRBRAFKITFLT3GRM4 | |
| SCHEMBL8563314 | 0.73 | CTSD (0.48) | CTSDKDRBRAFKITFLT3 | |
| SCHEMBL8564250 | 0.72 | KDR (0.60) | CTSDKDRBRAFKITFLT3 | |
| SCHEMBL28030477 | 0.68 | DDAH1 (0.54) | CTSDPOLBMEN1TSHRKMT2A | |
| SCHEMBL11375683 | 0.68 | NPC1 (0.56) | KDRHSPD1PTPN2PTPN1PTPN5 | |
| SCHEMBL15677877 | 0.67 | KDR (0.52) | KDRBRAFGRM4TRPV1MEN1 | |
| SCHEMBL18615348 | 0.66 | KDR (0.85) | KDRGRM4TRPV1CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |