Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 4/20 | 0.37 |
| ▸ | F10 | P00742 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL8895876 | 0.97 | ASIC3 (0.38) | ASIC3HTR6F10HRH3S1PR1 | |
| SCHEMBL8559578 | 0.94 | HTR6 (0.42) | HTR6HRH3S1PR1HDAC1 | |
| Hydrochloric Acid SCHEMBL8566255 | 0.93 | HTR6 (0.41) | HTR6HRH3S1PR1HDAC1 | |
| SCHEMBL8564139 | 0.88 | PTGER1 (0.35) | ASIC3HTR6F10S1PR1PLAU | |
| SCHEMBL8557059 | 0.87 | S1PR1 (0.43) | ASIC3HTR6F10S1PR1PLAU | |
| Hydrochloric Acid SCHEMBL8567567 | 0.87 | PTGER1 (0.36) | ASIC3HTR6F10S1PR1PLAU | |
| SCHEMBL8559518 | 0.85 | HRH3 (0.41) | HTR6HRH3S1PR1HDAC1 | |
| Hydrochloric Acid SCHEMBL8564996 | 0.84 | HRH3 (0.40) | HTR6HRH3S1PR1HDAC1 | |
| SCHEMBL8558614 | 0.83 | HTR6 (0.38) | HTR6HRH3S1PR1 | |
| SCHEMBL19642967 | 0.82 | PLAU (0.49) | ASIC3HTR6PLAUROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1048490-C | Cyclic derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | THOMAE GMBH DR K (DE) | 2000-01-19 | — | — | CN | claimed |
| EP-0612741-B1 | Cyclic derivatives, medicaments containing them and process for their preparation | THOMAE GMBH DR K (DE) | 1998-06-10 | — | — | EP | claimed |
| EP-0612741-A1 | Cyclic derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1994-08-31 | — | — | EP | claimed |
| JP-6256343-A | — | — | None | — | — | JP | disclosed |
| CN-1048490-C | Cyclic derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | THOMAE GMBH DR K (DE) | 2000-01-19 | — | — | CN | disclosed |
| US-5827849-A | HAVING INHIBITORY EFFECT ON INFLAMMATION AND BONE DEGRADATION, ANTITHROMBOTIC, ANTIAGGREGATORY AND TUMOR- OR METASTASIS-INHIBITING EFFECT | KARL THOMAE GMBH (DE) | 1998-10-27 | — | — | US | disclosed |
| EP-0612741-B1 | Cyclic derivatives, medicaments containing them and process for their preparation | THOMAE GMBH DR K (DE) | 1998-06-10 | — | — | EP | disclosed |
| US-5612335-A | ANTICOAGULANTS; COMBATING/PREVENTING DISEASES WHERE CELL AGGREGATES OCCUR OR CELL-MATRIX INTERACTIONS PLAY A PART | KARL THOMAE GMBH (DE) | 1997-03-18 | — | — | US | disclosed |
| US-5519036-A | IMIDAZOLIDINONES, ANTICOAGULANTS, CELL AGGREGATION PREVENTION | KARL THOMAE GMBH (DE) | 1996-05-21 | — | — | US | disclosed |
| CN-1099755-A | Cyclic derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | THOMAE GMBH DR K (DE) | 1995-03-08 | — | — | CN | disclosed |
| JP-H06256343-A | CYCLIC DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND METHOD FOR PREPARING THEM | DR KARL THOMAE GMBH | 1994-09-13 | — | — | JP | disclosed |
| EP-0612741-A1 | Cyclic derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1994-08-31 | — | — | EP | disclosed |