Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.35 |
| ▸ | ITGAV | P06756 | 2/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.35 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.35 |
| ▸ | ITGAL | P20701 | 1/20 | 0.35 |
| ▸ | CAD | P27708 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.32 |
| ▸ | IDUA | P35475 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4224698 | 1.00 | ITGB3 (0.35) | ITGB3ITGB1ITGAVITGB2ITGA2B | |
| SCHEMBL737201 | 0.79 | ITGB3 (0.34) | ITGB3ITGB1ITGAVITGB2ITGA2B | |
| SCHEMBL5498179 | 0.77 | ITGB3 (0.33) | ITGB3ITGB1ITGAVITGB2ITGA2B | |
| SCHEMBL7407237 | 0.77 | CAD (0.35) | ITGB3ITGB1ITGAVITGB2ITGA2B | |
| SCHEMBL9699985 | 0.76 | MCL1 (0.34) | ITGB3ITGB1ITGAVITGB2ITGA2B | |
| SCHEMBL2274342 | 0.74 | KMT2A (0.33) | ITGB3ITGB1ITGAVITGB2ITGA2B | |
| SCHEMBL380941 | 0.74 | KMT2A (0.33) | ITGB3ITGB1ITGAVITGB2ITGA2B | |
| SCHEMBL9699954 | 0.74 | KMT2A (0.33) | ITGB3ITGB1ITGAVITGB2ITGA2B | |
| SCHEMBL9699920 | 0.74 | KMT2A (0.33) | ITGB3ITGB1ITGAVITGB2ITGA2B | |
| SCHEMBL1644261 | 0.70 | HTT (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843997-A | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1998-12-01 | — | — | US | disclosed |
| US-5576323-A | CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| EP-0658539-A1 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1995-06-21 | — | — | EP | disclosed |