Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8564334 | 0.78 | CNR2 (0.36) | LMNAHRH1CYP2D6CHRM1KCNH2 | |
| SCHEMBL6570549 | 0.73 | PDPK1 (0.43) | LMNAPLA2G4ACES1SMN1; SMN2L3MBTL1 | |
| SCHEMBL8830241 | 0.72 | KDM4E (0.41) | LMNAHRH1CYP2D6KCNH2SMN1; SMN2 | |
| SCHEMBL20586652 | 0.71 | PLA2G4A (0.44) | LMNAPLA2G4ACES1SMN1; SMN2L3MBTL1 | |
| SCHEMBL14962698 | 0.68 | MAOA (0.44) | LMNAHRH1CYP2D6CHRM1KCNH2 | |
| SCHEMBL14968411 | 0.68 | MAOA (0.44) | LMNAHRH1CYP2D6CHRM1KCNH2 | |
| SCHEMBL28294365 | 0.67 | TSHR (0.41) | SMN1; SMN2MEN1KMT2ATSHRPOLB | |
| SCHEMBL6650369 | 0.67 | METAP2 (0.41) | LMNAPLA2G4ACES1SMN1; SMN2L3MBTL1 | |
| SCHEMBL6651146 | 0.67 | METAP2 (0.41) | LMNAPLA2G4ACES1SMN1; SMN2L3MBTL1 | |
| SCHEMBL6651144 | 0.67 | METAP2 (0.41) | LMNAPLA2G4ACES1SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821675-A1 | NOVEL HYDROXAMIC ACID AND AMINO-CARBOXYLATE COMPOUNDS AS METALLOPROTEASE AND TNF INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033176-A1 | NOVEL HYDROXAMIC ACID AND AMINO-CARBOXYLATE COMPOUNDS AS METALLOPROTEASE AND TNF INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-10-24 | — | — | WO | disclosed |