Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 6/20 | 0.56 |
| ▸ | AVPR1A | P37288 | 5/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558117 | 0.92 | AVPR2 (0.47) | AVPR2AVPR1AMEN1KMT2A | |
| SCHEMBL8557927 | 0.91 | AVPR2 (0.51) | AVPR2AVPR1A | |
| SCHEMBL8561432 | 0.91 | AVPR2 (0.55) | AVPR2AVPR1AMEN1KMT2AMAPT | |
| SCHEMBL8560617 | 0.90 | AVPR1A (0.49) | AVPR2AVPR1AHSD11B1MAPTRAB9A | |
| SCHEMBL8561944 | 0.90 | AVPR2 (0.48) | AVPR2AVPR1AHSD11B1MEN1KMT2A | |
| SCHEMBL8562938 | 0.90 | AVPR2 (0.45) | AVPR2AVPR1A | |
| SCHEMBL8563279 | 0.88 | AVPR2 (0.48) | AVPR2AVPR1AMEN1KMT2A | |
| SCHEMBL8561396 | 0.86 | AVPR2 (0.42) | AVPR2AVPR1AMAPT | |
| SCHEMBL8558188 | 0.85 | NPC1 (0.47) | AVPR2AVPR1AMEN1KMT2ARAB9A | |
| SCHEMBL8559867 | 0.84 | RAB9A (0.47) | AVPR2AVPR1ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |