Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 7/20 | 0.48 |
| ▸ | AVPR1A | P37288 | 7/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | GLP1R | P43220 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561432 | 0.93 | AVPR2 (0.55) | AVPR2AVPR1ARAB9ANPC1MEN1 | |
| SCHEMBL8558202 | 0.91 | HTR1F (0.51) | AVPR2AVPR1A | |
| SCHEMBL8563496 | 0.90 | AVPR2 (0.56) | AVPR2AVPR1ARAB9ANPC1MEN1 | |
| SCHEMBL8557927 | 0.89 | AVPR2 (0.51) | AVPR2AVPR1AGPR27 | |
| SCHEMBL8562470 | 0.88 | AVPR2 (0.40) | AVPR2AVPR1A | |
| SCHEMBL8557947 | 0.88 | AVPR2 (0.53) | AVPR2AVPR1ARAB9ANPC1 | |
| SCHEMBL8556938 | 0.87 | AVPR2 (0.56) | AVPR2AVPR1A | |
| SCHEMBL8559867 | 0.86 | RAB9A (0.47) | AVPR2AVPR1ARAB9ACHRM1 | |
| SCHEMBL8560074 | 0.85 | AVPR2 (0.48) | AVPR2AVPR1A | |
| SCHEMBL8557265 | 0.85 | AVPR2 (0.58) | AVPR2AVPR1ARAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |