Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 4/20 | 0.39 |
| ▸ | CTSS | P25774 | 4/20 | 0.39 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | HPN | P05981 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569264 | 1.00 | MMP2 (0.47) | MMP2MMP1MMP3MMP7MMP9 | |
| SCHEMBL8133560 | 0.86 | MMP1 (0.51) | MMP2MMP1MMP3MMP7MMP9 | |
| SCHEMBL9595462 | 0.86 | MMP1 (0.53) | MMP2MMP1MMP3MMP7MMP9 | |
| SCHEMBL9132706 | 0.77 | MMP1 (0.49) | MMP2MMP1MMP3MMP7MMP9 | |
| SCHEMBL8561448 | 0.76 | PTAFR (0.45) | MMP1MMP3MMP9MMP13MEN1 | |
| SCHEMBL8565202 | 0.75 | MMP2 (0.34) | MMP2MMP1MMP3MMP7MMP9 | |
| SCHEMBL8565588 | 0.75 | MMP2 (0.34) | MMP2MMP1MMP3MMP7MMP9 | |
| SCHEMBL8119786 | 0.75 | KMT2A (0.35) | MMP2MMP1MMP3MMP7MMP9 | |
| SCHEMBL8130832 | 0.75 | KDM4E (0.35) | MMP2MMP1MMP3MMP7MMP9 | |
| SCHEMBL8130834 | 0.75 | PTAFR (0.63) | CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0605434-B1 | IMIDAZO (4,5-C) PYRIDINE DERIVATIVES AS PAF ANTAGONISTS | BRITISH BIOTECH PHARM (GB) | 1998-08-19 | — | — | EP | disclosed |
| US-5446032-A | Platelet activsating factor antagonist | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-08-29 | — | — | US | disclosed |
| EP-0605434-A1 | IMIDAZO (4,5-C) PYRIDINE DERIVATIVES AS PAF ANTAGONISTS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1994-07-13 | — | — | EP | disclosed |
| WO-1993002080-A1 | IMIDAZO (4,5-C) PYRIDINE DERIVATIVES AS PAF ANTAGONISTS | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-02-04 | — | — | WO | disclosed |