Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 4/20 | 0.33 |
| ▸ | DRD4 | P21917 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 3/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | LGMN | Q99538 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562733 | 0.84 | DRD2 (0.49) | DRD3DRD4HSD17B10DRD2HTR2A | |
| SCHEMBL8562645 | 0.84 | DRD2 (0.49) | DRD3DRD4DRD2HTR2AHTR2C | |
| SCHEMBL8565094 | 0.83 | DHFR (0.40) | LCKPOLBDRD3DRD4ALDH1A1 | |
| SCHEMBL8571229 | 0.80 | ALDH1A1 (0.44) | CNR2POLBALDH1A1ALOX15MAPK10 | |
| SCHEMBL8563995 | 0.79 | DRD2 (0.54) | DRD3DRD4DRD2HTR2AHTR2C | |
| SCHEMBL8569163 | 0.79 | GRM2 (0.45) | — | |
| SCHEMBL8566284 | 0.79 | DRD4 (0.54) | DRD3DRD4ALDH1A1DRD2HTR2C | |
| SCHEMBL8570952 | 0.78 | HTR1A (0.43) | DRD3DRD4MAPK10DRD2HTR2A | |
| SCHEMBL8571687 | 0.77 | HTR1A (0.49) | DRD3DRD4DRD2HTR2C | |
| SCHEMBL8880284 | 0.76 | DHFR (0.50) | POLBALDH1A1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623620-B1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR (FR) | 1998-09-09 | — | — | EP | disclosed |
| US-5599812-A | ANTISEROTONINE AGENTS | ADIR ET COMPAGNIE (FR) | 1997-02-04 | — | — | US | disclosed |
| EP-0623620-A1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR ET COMPAGNIE (FR) | 1994-11-09 | — | — | EP | disclosed |