SCHEMBL8564151

SCHEMBL8564151

N[C@@](Cc1c[nH]c2ccccc12)(C(=O)NO)S(=O)(=O)c1ccc(F)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.49
SMN1; SMN2 Q16637 3/20 0.49
SIRT1 Q96EB6 1/20 0.46
MMP9 P14780 3/20 0.44
MMP2 P08253 2/20 0.44
CDK4 P11802 3/20 0.43
CCND1 P24385 3/20 0.43
SSTR3 P32745 1/20 0.43
MAPT P10636 3/20 0.43
ALDH1A1 P00352 3/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
HDAC8 Q9BY41 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8562962 0.90 GOT1 (0.45) SMN1; SMN2MMP9MMP2CDK4CCND1
SCHEMBL8560568 0.87 MMP9 (0.51) LMNASMN1; SMN2MMP9MMP2CDK4
SCHEMBL8559061 0.78 MEN1 (0.43) MMP9MMP2CDK4CCND1MAPT
SCHEMBL7382065 0.70 MMP9 (0.82) MMP9MMP2HDAC2HDAC8HDAC6
SCHEMBL7382067 0.70 MMP9 (0.82) MMP9MMP2HDAC2HDAC8HDAC6
SCHEMBL25244099 0.69 CYP19A1 (0.60) LMNASMN1; SMN2SSTR3MAPTALDH1A1
SCHEMBL2949291 0.68 CYP19A1 (0.81) SMN1; SMN2MAPTMEN1KMT2A
SCHEMBL24654260 0.68 GPR84 (0.52) LMNASIRT1CDK4CCND1SSTR3
SCHEMBL7468980 0.67 MMP9 (0.83) MMP9MMP2MEN1KMT2A
SCHEMBL7468990 0.67 MMP9 (0.83) MMP9MMP2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5804593-A FOR TREATMENT OF CONNECTIVE TISSUE DEGRADATION, OSTEO-, RHEUMATOID-, AND SEPTIC ARTHRITIS; OSTEOPENIAS, OSTEOPOROSIS, CORNEAL ULCERATION, PERIDONTAL DISEASE, GASTRIC ULCERS. PHARMACIA & UPJOHN COMPANY (US) 1998-09-08 US disclosed