Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 10/20 | 0.51 |
| ▸ | MMP2 | P08253 | 3/20 | 0.51 |
| ▸ | MMP13 | P45452 | 6/20 | 0.50 |
| ▸ | MMP1 | P03956 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562962 | 0.88 | GOT1 (0.45) | MMP9MMP2MEN1MAPTKMT2A | |
| SCHEMBL8564151 | 0.87 | LMNA (0.49) | MMP9MMP2MEN1MAPTKMT2A | |
| SCHEMBL8559061 | 0.82 | MEN1 (0.43) | MMP9MMP2MEN1MAPTKMT2A | |
| SCHEMBL8559637 | 0.80 | MMP13 (0.72) | MMP9MMP2MMP13MMP1 | |
| SCHEMBL7374860 | 0.72 | MMP9 (0.78) | MMP9MMP2KCNA5 | |
| SCHEMBL7379813 | 0.72 | MMP9 (0.78) | MMP9MMP2KCNA5 | |
| SCHEMBL25268137 | 0.72 | MMP9 (0.60) | MMP9MMP2MEN1MAPTKMT2A | |
| SCHEMBL8436167 | 0.71 | MMP13 (0.54) | MMP9MMP2MMP13MMP1 | |
| SCHEMBL8484087 | 0.70 | NPC1 (0.48) | NPC1POLBRAB9AMEN1MAPT | |
| SCHEMBL2947799 | 0.70 | KCNA5 (0.76) | MEN1MAPTKMT2ASMN1; SMN2KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5804593-A | FOR TREATMENT OF CONNECTIVE TISSUE DEGRADATION, OSTEO-, RHEUMATOID-, AND SEPTIC ARTHRITIS; OSTEOPENIAS, OSTEOPOROSIS, CORNEAL ULCERATION, PERIDONTAL DISEASE, GASTRIC ULCERS. | PHARMACIA & UPJOHN COMPANY (US) | 1998-09-08 | — | — | US | disclosed |