Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856161 | 0.86 | ACHE (0.38) | ACHEALDH1A1MAPK1RORCCACNA1G | |
| SCHEMBL856242 | 0.85 | ACHE (0.35) | ACHEALDH1A1MAPK1RORC | |
| SCHEMBL856116 | 0.84 | PTGDR2 (0.40) | ACHESIGMAR1RORC | |
| SCHEMBL857298 | 0.84 | ACHE (0.35) | ACHEMAPK1RORCCACNA1GCACNA1H | |
| SCHEMBL857343 | 0.84 | PTGDR2 (0.41) | ACHESIGMAR1 | |
| SCHEMBL3717468 | 0.83 | ACHE (0.32) | ACHETNKS2KDM4E | |
| SCHEMBL858891 | 0.74 | TP53 (0.35) | ACHETNKS2MAPK1 | |
| SCHEMBL856254 | 0.73 | PDK1 (0.32) | — | |
| SCHEMBL856424 | 0.72 | ACHE (0.37) | ACHETNKS2MAPK1CACNA1GCACNA1H | |
| SCHEMBL857154 | 0.70 | PDK1 (0.35) | TNKS2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |