Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 3/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | CCR6 | P51684 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856161 | 0.89 | ACHE (0.38) | ACHEMAPK1ALDH1A1RORC | |
| SCHEMBL857298 | 0.89 | ACHE (0.35) | ACHEMAPK1RORCDDB1CRBN | |
| SCHEMBL856425 | 0.85 | ACHE (0.36) | ACHEMAPK1ALDH1A1RORC | |
| SCHEMBL856116 | 0.82 | PTGDR2 (0.40) | ACHERORC | |
| SCHEMBL857343 | 0.81 | PTGDR2 (0.41) | ACHE | |
| SCHEMBL857154 | 0.68 | PDK1 (0.35) | MAPK1 | |
| SCHEMBL3723441 | 0.68 | ACHE (0.35) | ACHEALDH1A1 | |
| SCHEMBL856626 | 0.68 | AADAT (0.43) | — | |
| SCHEMBL858958 | 0.66 | PDK1 (0.33) | ACHEMAPK1 | |
| SCHEMBL856424 | 0.66 | ACHE (0.37) | ACHEMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |