Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 11/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 11/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561280 | 0.87 | LTB4R (0.51) | LTB4RLTB4R2 | |
| SCHEMBL27296155 | 0.86 | L3MBTL1 (0.46) | LTB4RLTB4R2FFAR4L3MBTL1PTGER1 | |
| SCHEMBL27300408 | 0.81 | LTB4R (0.54) | LTB4RLTB4R2FFAR4PTGER1RXRA | |
| SCHEMBL8568669 | 0.80 | CYP11B1 (0.47) | FFAR4L3MBTL1PTGER1CYP11B1CYP11B2 | |
| SCHEMBL6902570 | 0.79 | LTB4R (0.52) | LTB4RLTB4R2 | |
| SCHEMBL6757535 | 0.77 | LTB4R (0.50) | LTB4RLTB4R2 | |
| SCHEMBL6756183 | 0.75 | LTB4R (0.48) | LTB4RLTB4R2 | |
| SCHEMBL8568443 | 0.74 | LTB4R (0.77) | LTB4RLTB4R2FFAR4PTGER1PTGER4 | |
| Iodide SCHEMBL8565212 | 0.74 | LTB4R (0.47) | LTB4RLTB4R2 | |
| SCHEMBL8566998 | 0.74 | LTB4R (0.56) | LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544488-B1 | Substituted phenyl phenol leukotriene antagonists | LILLY CO ELI (US) | 1998-03-11 | — | — | EP | disclosed |
| WO-1996036347-A1 | USE OF LEUKOTRIENE ANTAGONISTS FOR ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1996-11-21 | — | — | WO | disclosed |
| EP-0743064-A1 | Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease | ELI LILLY AND COMPANY (US) | 1996-11-20 | — | — | EP | disclosed |
| US-5462954-A | Antiinflammatory, antiallergens; treating asthma | ELI LILLY AND COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0544488-A2 | Substituted phenyl phenol leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |