Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | DHFR | P00374 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6963693 | 0.83 | MAPT (0.60) | LMNAMAPTSMN1; SMN2DHFRMEN1 | |
| SCHEMBL6944030 | 0.80 | ALOX5 (0.53) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL27581731 | 0.78 | PDE7A (0.67) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL11355337 | 0.77 | ALDH1A1 (0.44) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL20379380 | 0.77 | MAPT (0.52) | LMNAMAPTSMN1; SMN2DHFRMEN1 | |
| SCHEMBL7606463 | 0.77 | PDE7A (0.67) | LMNAMAPTSMN1; SMN2DHFRMEN1 | |
| SCHEMBL2418894 | 0.77 | SMN1; SMN2 (0.52) | LMNAMAPTSMN1; SMN2DHFRMEN1 | |
| SCHEMBL22133428 | 0.77 | ALDH1A1 (0.65) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL20379425 | 0.77 | PDE7A (0.61) | LMNAMAPTSMN1; SMN2DHFRMEN1 | |
| SCHEMBL29881314 | 0.77 | PDE7A (0.61) | LMNAMAPTSMN1; SMN2DHFRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |
| US-4275077-A | Insecticidal acyl urea derivatives | CELAMERCK GMBH & CO. KG (DE) | 1981-06-23 | — | — | US | disclosed |