Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 2/20 | 0.48 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168606 | 0.92 | OPRL1 (0.52) | CCR5OPRL1ACHECHRM3CHRM2 | |
| SCHEMBL29445321 | 0.92 | OPRL1 (0.52) | CCR5OPRL1ACHECHRM3CHRM2 | |
| SCHEMBL8570739 | 0.90 | CHRM2 (0.54) | CCR5TRPV6SIGMAR1OPRL1ACHE | |
| SCHEMBL8565038 | 0.88 | CHRM3 (0.47) | CCR5TRPV6SIGMAR1OPRL1ACHE | |
| SCHEMBL8569508 | 0.88 | MEN1 (0.53) | CCR5SIGMAR1OPRL1ACHECHRM3 | |
| SCHEMBL6168165 | 0.86 | CHRM3 (0.49) | SIGMAR1OPRL1ACHECHRM3CHRM2 | |
| SCHEMBL8570369 | 0.85 | CHRM3 (0.50) | OPRL1ACHECHRM3CHRM2 | |
| SCHEMBL8570694 | 0.85 | PARP1 (0.49) | TRPV6SIGMAR1OPRL1CHRM3CHRM2 | |
| SCHEMBL6167277 | 0.85 | CHRM3 (0.53) | SIGMAR1OPRL1ACHECHRM3CHRM2 | |
| SCHEMBL8563897 | 0.84 | OPRL1 (0.43) | CCR5OPRL1ACHECHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626373-B1 | Quinazolinone derivatives | SUMITOMO PHARMA (JP) | 1998-12-23 | — | — | EP | disclosed |
| US-5556860-A | ANTIISCHEMIC AGENTS, BRAIN DISORDERS AND BLOOD METAL CONCENTRATIONS AND KIDNEY DISEASE | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0626373-A1 | Quinazolinone derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-11-30 | — | — | EP | disclosed |