Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL179267 | 0.75 | HDAC8 (0.35) | HDAC8HSP90AA1KDM4EALDH1A1KMT2A | |
| SCHEMBL31175998 | 0.73 | HDAC8 (0.33) | HDAC8HSP90AA1KDM4EALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL6587339 | 0.73 | KDM4E (0.36) | HDAC8HSP90AA1KDM4EALDH1A1KMT2A | |
| SCHEMBL31194454 | 0.73 | HDAC8 (0.33) | HDAC8HSP90AA1KDM4EALDH1A1KMT2A | |
| SCHEMBL28198650 | 0.73 | HDAC8 (0.33) | HDAC8HSP90AA1KDM4EALDH1A1KMT2A | |
| SCHEMBL19814728 | 0.71 | HSP90AA1 (0.38) | HDAC8HSP90AA1 | |
| SCHEMBL31692011 | 0.71 | HDAC8 (0.32) | HDAC8HSP90AA1 | |
| SCHEMBL22047644 | 0.71 | HDAC8 (0.32) | HDAC8HSP90AA1 | |
| SCHEMBL5711286 | 0.71 | HDAC8 (0.32) | HDAC8HSP90AA1 | |
| SCHEMBL658284 | 0.71 | HDAC8 (0.32) | HDAC8HSP90AA1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129389-B2 | Substituted oxindole derivatives, medicaments containing the latter and use thereof | ABBOTT GMBH & CO. KG (DE) | 2012-03-06 | — | — | US | disclosed |
| US-20090186904-A1 | Substituted Oxindole Derivatives, Medicaments Containing the Latter and Use Thereof | ABBOTT GMBH & CO. KG | 2009-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186904-A1 | Substituted Oxindole Derivatives, Medicaments Containing the Latter and Use Thereof | OXTR, AVPR2, AVPR1B | HDAC8 3033/4885HSP90AA1 1676/4885KDM4E 3956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.