Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.32 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6587339 | 0.97 | KDM4E (0.36) | HDAC8HSP90AA1KDM4EALDH1A1KMT2A | |
| SCHEMBL31175998 | 0.97 | HDAC8 (0.33) | HDAC8HSP90AA1KDM4EALDH1A1KMT2A | |
| SCHEMBL28198650 | 0.97 | HDAC8 (0.33) | HDAC8HSP90AA1KDM4EALDH1A1KMT2A | |
| SCHEMBL31194454 | 0.97 | HDAC8 (0.33) | HDAC8HSP90AA1KDM4EALDH1A1KMT2A | |
| SCHEMBL28130822 | 0.78 | — | — | |
| SCHEMBL28130826 | 0.76 | — | — | |
| SCHEMBL19814728 | 0.75 | HSP90AA1 (0.38) | HDAC8HSP90AA1NOS3NOS1NOS2 | |
| SCHEMBL31692011 | 0.75 | HDAC8 (0.32) | HDAC8HSP90AA1 | |
| SCHEMBL22047644 | 0.75 | HDAC8 (0.32) | HDAC8HSP90AA1 | |
| SCHEMBL5711286 | 0.75 | HDAC8 (0.32) | HDAC8HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1802 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114478628-A | Application of tert-butyl pyrimidine triazole copper [ I ] dinuclear complex in stimulus response luminescent and photochromic material | 江西理工大学 | 2022-05-13 | — | — | CN | claimed |
| CN-105452233-B | Piperidine and azepane derivatives as prokineticin receptor modulators | 武田药品工业株式会社 | 2017-12-08 | — | — | CN | claimed |
| EP-0342742-B1 | Process for the preparation of 2-alkylpyrimidines | DOWELANCO (US) | 1994-11-02 | — | — | EP | claimed |
| US-4999427-A | Prepared From 1,3-Diaminopropane And An Alkanecarboxylic Acid In A Continuous Vapor Phase Process | DOWELANCO (US) | 1991-03-12 | — | — | US | claimed |
| EP-0342742-A1 | Process for the preparation of 2-alkylpyrimidines | DowElanco (US) | 1989-11-23 | — | — | EP | claimed |
| EP-0117883-B1 | PREPARATION OF 2-T-BUTYL-5-HYDROXYPYRIMIDINE BY HYDROLYSIS OF 2-T-BUTYL-5--BROMO/CHLOROPYRIMIDINE | THE DOW CHEMICAL COMPANY (US) | 1987-01-28 | — | — | EP | claimed |
| EP-0102741-B1 | PREPARATION OF 2-T-BUTYL-5-CHLOROPYRIMIDINE | THE DOW CHEMICAL COMPANY (US) | 1986-12-30 | — | — | EP | claimed |
| US-4486590-A | NONCATALYTIC CHLORINATION IN ACID SOLUTION | THE DOW CHEMICAL COMPANY (US) | 1984-12-04 | — | — | US | claimed |
| EP-0117883-A1 | Preparation of 2-t-butyl-5-hydroxypyrimidine by hydrolysis of 2-t-butyl-5--bromo/chloropyrimidine | THE DOW CHEMICAL COMPANY (US) | 1984-09-12 | — | — | EP | claimed |
| EP-0102741-A1 | Preparation of 2-t-butyl-5-chloropyrimidine | THE DOW CHEMICAL COMPANY (US) | 1984-03-14 | — | — | EP | claimed |
| US-20260098032-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION | PMV PHARMACEUTICALS INC (US) | 2026-04-09 | — | — | US | disclosed |
| US-12428406-B2 | Methods and compounds for restoring mutant p53 function | PMV PHARMACEUTICALS, INC. (US) | 2025-09-30 | — | — | US | disclosed |
| US-12202826-B2 | N-pyridinyl acetamide derivatives as inhibitors of the Wnt signaling pathway | REDX PHARMA PLC (GB) | 2025-01-21 | — | — | US | disclosed |
| CN-114478628-B | Application of tert-butyl pyrimidine copper (I) triazole dinuclear complex in stimulus response luminescent color-changing material | 江西理工大学 | 2024-10-18 | — | — | CN | disclosed |
| US-12043623-B2 | Purinones as ubiquitin-specific protease 1 inhibitors | FORMA THERAPEUTICS, INC. (US) | 2024-07-23 | — | — | US | disclosed |
| EP-0102741-A1 | Preparation of 2-t-butyl-5-chloropyrimidine | THE DOW CHEMICAL COMPANY (US) | 1984-03-14 | — | — | EP | disclosed |
| EP-0102741-A1 | Preparation of 2-t-butyl-5-chloropyrimidine | THE DOW CHEMICAL COMPANY (US) | 1984-03-14 | — | — | EP | disclosed |
| EP-0097451-A1 | 2-Alkyl-5-pyrimidines | THE DOW CHEMICAL COMPANY (US) | 1984-01-04 | — | — | EP | disclosed |
| US-4379930-A | CATALYTIC HYDROLYSIS OF 2-T-BUTYL-5-PYRIMIDINE USING DIBUTYL DISULFIDE, ELEMENTAL SULFUR AND 2-PICOLINE-N-OXIDE AS CATALYST SYSTEM | THE DOW CHEMICAL COMPANY (US) | 1983-04-12 | — | — | US | disclosed |
| US-4376201-A | Preparation of 2-alkylpyrimidines | THE DOW CHEMICAL COMPANY (US) | 1983-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12202826-B2 | N-pyridinyl acetamide derivatives as inhibitors of the Wnt signaling pathway | WNT1, WNT3, CTNNB1 | HDAC8 1643/4885HSP90AA1 4585/4885KDM4E 1635/4885 |
| US-12428406-B2 | Methods and compounds for restoring mutant p53 function | TP53, TP53BP1, KRAS | HDAC8 1864/4885HSP90AA1 481/4885KDM4E 2994/4885 |
| US-20260098032-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION | TP53, TP53BP1, MDM2 | HDAC8 3113/4885HSP90AA1 1800/4885KDM4E 1371/4885 |
| US-12043623-B2 | Purinones as ubiquitin-specific protease 1 inhibitors | USP1, UBA1, UBXN1 | HDAC8 2639/4885HSP90AA1 1548/4885KDM4E 1002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.