Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565482 | 0.84 | ADRB2 (0.42) | MEN1ALDH1A1KMT2AADRB2NCF1 | |
| SCHEMBL9024092 | 0.77 | ADRB2 (0.48) | ADRB2NCF1NOS3NOS2PARP1 | |
| SCHEMBL7488303 | 0.75 | KDM1A (0.54) | MEN1KMT2ANCF1DHFRKDR | |
| SCHEMBL1980284 | 0.75 | NR4A2 (0.56) | ADRB2NCF1NOS3NOS2PARP1 | |
| SCHEMBL7809666 | 0.73 | ADRB2 (0.36) | ALDH1A1ADRB2NCF1PARP1KIF11 | |
| SCHEMBL7809674 | 0.73 | TDP1 (0.40) | ALDH1A1ADRB2NCF1KDRDYRK1A | |
| SCHEMBL27619316 | 0.72 | GRM4 (0.44) | ADRB2NCF1NOS3NOS2PARP1 | |
| SCHEMBL4419333 | 0.71 | RAC1 (0.48) | KMT2AADRB2NCF1NOS3NOS2 | |
| SCHEMBL5050795 | 0.71 | PDGFRA (0.61) | KDREGFR | |
| SCHEMBL4167757 | 0.70 | RAC1 (0.54) | ADRB2NCF1NOS3NOS2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |