Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 4/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.37 |
| ▸ | KDR | P35968 | 4/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.37 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.37 |
| ▸ | CLK2 | P49760 | 2/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565612 | 0.84 | MEN1 (0.48) | ADRB2NCF1PARP1GAKGRM4 | |
| SCHEMBL9024092 | 0.77 | ADRB2 (0.48) | ADRB2NCF1PARP1GAKGRM4 | |
| SCHEMBL8560845 | 0.75 | NCF1 (0.42) | ADRB2NCF1SLC22A12KDRMEN1 | |
| SCHEMBL27619316 | 0.72 | GRM4 (0.44) | ADRB2NCF1PARP1GAKGRM4 | |
| SCHEMBL4419333 | 0.71 | RAC1 (0.48) | ADRB2NCF1PARP1GAKGRM4 | |
| SCHEMBL7809666 | 0.70 | ADRB2 (0.36) | ADRB2NCF1PARP1SLC22A12GSK3A | |
| SCHEMBL7809674 | 0.70 | TDP1 (0.40) | ADRB2NCF1SLC22A12KDRDYRK1A | |
| SCHEMBL8560980 | 0.70 | KDR (0.56) | GRM4KDRALDH1A1 | |
| SCHEMBL22854 | 0.70 | ADRB2 (0.52) | ADRB2NCF1PARP1GAKGRM4 | |
| SCHEMBL31121093 | 0.70 | ADRB2 (0.52) | ADRB2NCF1PARP1GAKGRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |