SCHEMBL8565685

SCHEMBL8565685

C[C@@]1(c2cc3nc(Cl)ccc3o2)CCCN1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 7/20 0.34
PARP2 Q9UGN5 4/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
LMNA P02545 2/20 0.31
CYP1A2 P05177 1/20 0.31
MAPT P10636 1/20 0.31
THRB P10828 1/20 0.31
ALOX15 P16050 1/20 0.31
MAPK1 P28482 1/20 0.31
TNKS O95271 1/20 0.31
PARP14 Q460N5 1/20 0.31
PARP10 Q53GL7 1/20 0.31
PARP12 Q9H0J9 1/20 0.31
TNKS2 Q9H2K2 1/20 0.31
PARP4 Q9UKK3 1/20 0.31
PARP3 Q9Y6F1 1/20 0.31
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8570853 1.00 PARP1 (0.34) PARP1PARP2MEN1KMT2ALMNA
SCHEMBL8567997 0.85 CDC7 (0.32) PARP1PARP2MAPTTNKSPARP14
SCHEMBL8564031 0.85 CDC7 (0.32) PARP1PARP2MAPTTNKSPARP14
SCHEMBL8128487 0.82 PARP1 (0.34) PARP1PARP2
SCHEMBL8130242 0.80 PARP1 (0.33) PARP1
SCHEMBL8566838 0.80 PARP1 (0.33) PARP1
SCHEMBL8569094 0.77 NPC1 (0.37) PARP1PARP2LMNAMAPTTHRB
SCHEMBL8567488 0.77 CHRNB2 (0.45) PARP1PARP2TNKSPARP14PARP10
SCHEMBL8120739 0.76 PARP1 (0.39) PARP1PARP2TNKSPARP14PARP10
Hydrochloric Acid SCHEMBL8120773 0.73 KDM4E (0.38) PARP1CYP1A2MAPTMAPK1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0842178-A1 FUROPYRIDINE, THIENOPYRIDINE, PYRROLOPYRIDINE AND RELATED PYRIMIDINE, PYRIDAZINE AND TRIAZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 1998-05-20 EP claimed
WO-1997005139-A1 FUROPYRIDINE, THIENOPYRIDINE, PYRROLOPYRIDINE AND RELATED PYRIMIDINE, PYRIDAZINE AND TRIAZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1997-02-13 WO claimed
EP-0842178-A1 FUROPYRIDINE, THIENOPYRIDINE, PYRROLOPYRIDINE AND RELATED PYRIMIDINE, PYRIDAZINE AND TRIAZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 1998-05-20 EP disclosed
WO-1997005139-A1 FUROPYRIDINE, THIENOPYRIDINE, PYRROLOPYRIDINE AND RELATED PYRIMIDINE, PYRIDAZINE AND TRIAZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1997-02-13 WO disclosed