Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 5/20 | 0.52 |
| ▸ | TACR1 | P25103 | 3/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8570065 | 0.82 | POLQ (0.45) | POLQTACR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12202180 | 0.80 | POLQ (0.57) | POLQOPRK1GRIN2BGRIN1KMT2A | |
| SCHEMBL8720333 | 0.78 | KMT2A (0.51) | POLQSLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL8567776 | 0.78 | KMT2A (0.43) | POLQTACR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8566845 | 0.76 | CD274 (0.53) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL8572406 | 0.75 | POLQ (0.53) | POLQTACR1 | |
| SCHEMBL2393653 | 0.75 | TACR1 (0.47) | POLQTACR1GRIN2BGRIN1FFAR4 | |
| SCHEMBL8565708 | 0.75 | TACR1 (0.60) | POLQTACR1OPRK1CNR2PDCD1 | |
| SCHEMBL8692412 | 0.74 | FABP4 (0.54) | POLQFABP4 | |
| SCHEMBL9890721 | 0.70 | MLNR (0.47) | SLC6A4SLC6A3MEN1KMT2AFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | claimed |