Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.53 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8720333 | 0.84 | KMT2A (0.51) | CD274PDCD1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8567776 | 0.84 | KMT2A (0.43) | CD274PDCD1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8570065 | 0.81 | POLQ (0.45) | CD274PDCD1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9890713 | 0.76 | FFAR1 (0.42) | NR4A2ALDH1A1 | |
| SCHEMBL8565707 | 0.76 | POLQ (0.52) | CD274PDCD1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8566848 | 0.75 | TACR1 (0.53) | CD274PDCD1PTGS1KMT2AMEN1 | |
| SCHEMBL8572406 | 0.73 | POLQ (0.53) | ALDH1A1 | |
| SCHEMBL9890715 | 0.73 | CYP2C19 (0.49) | KMT2AMEN1NR4A2LTB4R2SLC6A4 | |
| SCHEMBL9890721 | 0.73 | MLNR (0.47) | KMT2AMEN1LTB4R2SLC6A4SLC6A3 | |
| SCHEMBL9890717 | 0.72 | CHRM1 (0.65) | NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | disclosed |