Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 15/20 | 0.39 |
| ▸ | CDK2 | P24941 | 14/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8558006 | 0.99 | CDK4 (0.38) | CDK4CDK2CDK1CCNE1EHMT2 | |
| SCHEMBL8559967 | 0.83 | PDGFRA (0.48) | EHMT2PDGFRAABL1LCKACVR1 | |
| Water SCHEMBL8328226 | 0.82 | PDGFRA (0.47) | EHMT2PDGFRALCKSLC2A1 | |
| Hydrochloric Acid SCHEMBL8566059 | 0.82 | HTT (0.50) | EHMT2PDGFRALCKSLC2A1 | |
| SCHEMBL8567323 | 0.82 | MAPKAPK2 (0.46) | CDK4CDK2EHMT2PDGFRALCK | |
| SCHEMBL8560347 | 0.81 | ERBB2 (0.52) | EHMT2PDGFRBKDRSLC2A1 | |
| Hydrochloric Acid SCHEMBL8566240 | 0.80 | ERBB2 (0.51) | EHMT2PDGFRBKDRSLC2A1 | |
| SCHEMBL8568868 | 0.79 | HRH3 (0.49) | CDK4EHMT2ABL1LCKKDR | |
| SCHEMBL8561756 | 0.79 | MAPT (0.51) | SLC2A1 | |
| Hydrochloric Acid SCHEMBL8565861 | 0.78 | MAPT (0.51) | SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |
| WO-1993013097-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |