Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.56 |
| ▸ | BRAF | P15056 | 6/20 | 0.56 |
| ▸ | FLT3 | P36888 | 3/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565704 | 0.89 | KDR (0.58) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8561654 | 0.85 | KDR (0.58) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8562462 | 0.76 | KDR (0.54) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8564250 | 0.75 | KDR (0.60) | KDRBRAFFLT3KITTRPV1 | |
| SCHEMBL717224 | 0.75 | KDR (0.63) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL22164160 | 0.74 | TRPV1 (0.48) | KDRBRAFTRPV1LMNAMAPT | |
| SCHEMBL8562560 | 0.74 | BRAF (0.64) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8563685 | 0.73 | KDR (0.54) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8561054 | 0.72 | CTSD (0.57) | KDRBRAFFLT3KITLMNA | |
| SCHEMBL8562810 | 0.72 | KDR (0.57) | KDRBRAFFLT3KITEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |