Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.45 |
| ▸ | GCGR | P47871 | 2/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 6/20 | 0.43 |
| ▸ | AKT1 | P31749 | 4/20 | 0.43 |
| ▸ | AKT2 | P31751 | 4/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13743031 | 0.87 | GRIA1 (0.45) | PTGS1PTGS2GRIA1AKT1AKT2 | |
| SCHEMBL13866614 | 0.84 | AKT1 (0.42) | PTGS1PTGS2GRIA1AKT1AKT2 | |
| SCHEMBL213843 | 0.83 | PTGS2 (0.58) | PTGS1PTGS2GRIA1AKT1AKT2 | |
| SCHEMBL13751999 | 0.81 | AKT1 (0.43) | PTGS1PTGS2GRIA1AKT1AKT2 | |
| SCHEMBL213844 | 0.77 | PTGS2 (0.43) | PTGS1PTGS2GRIA1AKT1AKT2 | |
| SCHEMBL8564136 | 0.75 | ALDH1A1 (0.53) | PTGS1PTGS2MAPK13MAPK12MAPK11 | |
| SCHEMBL6102319 | 0.73 | MAPT (0.53) | PTGS1PTGS2MAPK13MAPK12MAPK11 | |
| SCHEMBL8566547 | 0.72 | AKT1 (0.55) | PTGS1PTGS2AKT1AKT2 | |
| SCHEMBL8566479 | 0.71 | PTGS2 (0.56) | PTGS1PTGS2 | |
| SCHEMBL5266214 | 0.70 | MAPK14 (0.54) | PTGS1PTGS2MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819127-A1 | IMIDAZO [1,2-a]PYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031509-A1 | IMIDAZO[1,2-a]PYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1996-10-10 | — | — | WO | disclosed |