Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 3/20 | 0.66 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.66 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.66 |
| ▸ | CHRNA10 | Q9GZZ6 | 3/20 | 0.66 |
| ▸ | CHRNA9 | Q9UGM1 | 3/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1196073 | 0.88 | LTA4H (0.58) | CHRNB4CHRNA3CHRNA7CHRNA10CHRNA9 | |
| SCHEMBL7089083 | 0.81 | NPC1 (0.62) | CHRNB4CHRNA3CHRNA7CHRNA10CHRNA9 | |
| SCHEMBL9983791 | 0.80 | MAPK1 (0.66) | CHRNB4CHRNA3CHRNA7CHRNA10CHRNA9 | |
| SCHEMBL30041284 | 0.80 | MAPK1 (0.66) | CHRNB4CHRNA3CHRNA7CHRNA10CHRNA9 | |
| SCHEMBL412385 | 0.79 | RIPK1 (0.57) | MAPK1BRAF | |
| SCHEMBL31757556 | 0.77 | CHRNB4 (0.47) | CHRNB4CHRNA3CHRNA7CHRNA10CHRNA9 | |
| SCHEMBL13554406 | 0.77 | CYP3A4 (0.50) | CHRNB4CHRNA3CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL3901006 | 0.75 | NPC1 (0.64) | CHRNB4CHRNA3CHRNA7CHRNA10CHRNA9 | |
| SCHEMBL6769982 | 0.75 | LTA4H (0.58) | CHRNB4CHRNA3CHRNA7CHRNA10CHRNA9 | |
| SCHEMBL5850255 | 0.75 | NPC1 (0.79) | NPC1LTA4HCYP17A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |