Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 10/20 | 0.38 |
| ▸ | HTR3B | O95264 | 10/20 | 0.38 |
| ▸ | HTR3A | P46098 | 10/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 10/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 10/20 | 0.38 |
| ▸ | HTR1A | P08908 | 8/20 | 0.38 |
| ▸ | HTR2C | P28335 | 6/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8570625 | 0.79 | HTR3E (0.55) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8570035 | 0.76 | HTR3E (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8564870 | 0.70 | PTPN1 (0.40) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL21208492 | 0.70 | TYMS (0.46) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL8569855 | 0.68 | PTPN1 (0.61) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL10339690 | 0.68 | KDM4E (0.63) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL17028371 | 0.67 | KDM4E (0.42) | PTPN1KDM4EALDH1A1GLAGAA | |
| SCHEMBL14829065 | 0.67 | HRH4 (0.38) | HTR3APTPN1KDM4EALDH1A1GLA | |
| SCHEMBL120846 | 0.67 | MAPK8 (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL30578099 | 0.67 | MAPK8 (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623620-B1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR (FR) | 1998-09-09 | — | — | EP | disclosed |
| US-5599812-A | ANTISEROTONINE AGENTS | ADIR ET COMPAGNIE (FR) | 1997-02-04 | — | — | US | disclosed |
| EP-0623620-A1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR ET COMPAGNIE (FR) | 1994-11-09 | — | — | EP | disclosed |