Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | PLK1 | P53350 | 2/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569636 | 0.89 | HTT (0.45) | HTTPLK1PDCD1CD274GAA | |
| SCHEMBL8573482 | 0.83 | HTT (0.47) | HTTPLK1PDCD1CD274GAA | |
| SCHEMBL7454511 | 0.81 | GAA (0.45) | HTTPLK1PDCD1CD274GAA | |
| SCHEMBL7855360 | 0.81 | PDK2 (0.44) | HTTPLK1GAAKDM4EALDH1A1 | |
| SCHEMBL8567754 | 0.81 | HTT (0.51) | HTTPLK1GAAPOLBKDM4E | |
| SCHEMBL7445923 | 0.80 | L3MBTL1 (0.48) | PLK1GAAKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL8197604 | 0.78 | SMN1; SMN2 (0.45) | HTTPDCD1CD274KDM4EALDH1A1 | |
| SCHEMBL7856360 | 0.78 | PDK2 (0.44) | HTTPLK1GAAKDM4EALDH1A1 | |
| SCHEMBL15472559 | 0.76 | CHRNB2 (0.56) | HTTPLK1GAAPOLBKDM4E | |
| SCHEMBL7855891 | 0.74 | FGFR1 (0.40) | HTTPLK1GAAPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | disclosed |