Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.50 |
| ▸ | MAOB | P27338 | 5/20 | 0.50 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.50 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.50 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.50 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.50 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | HNF4A | P41235 | 1/20 | 0.44 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21035765 | 0.86 | LCK (0.61) | MAOAMAOBKLKB1CTSBMMP9 | |
| SCHEMBL13302505 | 0.86 | KLKB1 (0.68) | MAOAMAOBKLKB1CTSBMMP9 | |
| SCHEMBL11556307 | 0.85 | KDM4E (0.57) | MAOAMAOBKLKB1CTSBMMP9 | |
| SCHEMBL925372 | 0.84 | TRPA1 (0.57) | MAOAMAOBKLKB1CTSBMMP9 | |
| SCHEMBL11938337 | 0.84 | ALDH1A1 (0.52) | MAOAMAOBPKMCYP4F2CYP4A11 | |
| SCHEMBL21632307 | 0.82 | PLG (0.49) | MAOAMAOBKLKB1CTSBMMP9 | |
| SCHEMBL11337098 | 0.82 | MAOA (0.53) | MAOAMAOBKLKB1CTSBMMP9 | |
| SCHEMBL312283 | 0.82 | MAOA (0.49) | MAOAMAOBKLKB1CTSBMMP9 | |
| SCHEMBL4878532 | 0.82 | KLKB1 (0.74) | KLKB1CTSBMMP9DNMT1DNMT3B | |
| SCHEMBL31550006 | 0.82 | KLKB1 (0.74) | KLKB1CTSBMMP9DNMT1DNMT3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11760773-B2 | Small molecule drug conjugates of gemcitabine monophosphate | MAVERIX ONCOLOGY, INC. (US) | 2023-09-19 | — | — | US | disclosed |
| EP-0431943-B1 | Spiro(pyran)piperidine derivatives | MERCK & CO INC (US) | 1998-07-15 | — | — | EP | disclosed |
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0431943-A2 | Nitrogen-containing spirocycles | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |
| US-4778757-A | ADDING FIRST REAGENT OF OXIDASE, PEROXIDASE AND PHENOLIC CHROMOGEN FOLLOWED BY ADDING COUPLER; ACCURATE COLORIMETRY | TOYO BOSEKI KABUSHIKI KAISHA (JP) | 1988-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11760773-B2 | Small molecule drug conjugates of gemcitabine monophosphate | ZYX, SLC7A5, GMPS | MAOA 4467/4885MAOB 3534/4885KLKB1 4198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.