Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 8/20 | 0.49 |
| ▸ | DRD2 | P14416 | 7/20 | 0.49 |
| ▸ | DRD3 | P35462 | 6/20 | 0.49 |
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8574032 | 0.79 | ACHE (0.52) | ACHE | |
| SCHEMBL12000243 | 0.73 | DRD4 (0.64) | DRD4DRD2DRD3MAPTNPSR1 | |
| Maleic Acid SCHEMBL8574182 | 0.73 | ACHE (0.49) | DRD2ACHESIGMAR1 | |
| Fumaric Acid SCHEMBL8574186 | 0.73 | ACHE (0.49) | DRD2ACHESIGMAR1 | |
| SCHEMBL8569904 | 0.70 | ACHE (0.53) | ACHE | |
| SCHEMBL13533025 | 0.69 | HTR1A (0.83) | DRD2HTR1A | |
| SCHEMBL8131885 | 0.69 | ATM (0.67) | DRD4DRD2DRD3NCF1SIGMAR1 | |
| SCHEMBL6986033 | 0.69 | ACHE (0.70) | ACHESIGMAR1 | |
| SCHEMBL6864941 | 0.68 | DRD4 (0.81) | DRD4DRD2DRD3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6991446 | 0.68 | ACHE (0.68) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750542-A | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors | PFIZER (US) | 1998-05-12 | — | — | US | disclosed |