Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 7/20 | 0.43 |
| ▸ | HTR2C known ✓ | P28335 | 7/20 | 0.43 |
| ▸ | HTR2B known ✓ | P41595 | 7/20 | 0.43 |
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.43 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 9/20 | 0.49 |
| ▸ | BCHE | P06276 | 3/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8574182 | 1.00 | ACHE (0.49) | ACHEBCHEHTR2AHTR2CHTR2B | |
| Fumaric Acid SCHEMBL8572224 | 0.93 | ACHE (0.50) | ACHEBCHEHTR2AHTR2CHTR2B | |
| Maleic Acid SCHEMBL8572220 | 0.93 | ACHE (0.50) | ACHEBCHEHTR2AHTR2CHTR2B | |
| SCHEMBL8574032 | 0.92 | ACHE (0.52) | ACHEBCHEMEN1KMT2A | |
| SCHEMBL8569904 | 0.84 | ACHE (0.53) | ACHEBCHEMEN1KMT2A | |
| Maleic Acid SCHEMBL8572750 | 0.81 | ACHE (0.45) | ACHEHTR2AHTR2CHTR2BSIGMAR1 | |
| Fumaric Acid SCHEMBL8572755 | 0.81 | ACHE (0.45) | ACHEHTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL8574179 | 0.77 | ACHE (0.52) | ACHEBCHE | |
| SCHEMBL8574931 | 0.77 | ACHE (0.53) | ACHEBCHEDRD2MEN1KMT2A | |
| Fumaric Acid SCHEMBL6986323 | 0.73 | ACHE (0.84) | ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750542-A | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors | PFIZER (US) | 1998-05-12 | — | — | US | disclosed |