Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C4 | P17516 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.52 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.49 |
| ▸ | CTSV | O60911 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6545840 | 0.88 | AKR1C4 (0.52) | AKR1C4AKR1C3AKR1C2AKR1C1MAPT | |
| SCHEMBL7752904 | 0.84 | AKR1C4 (0.67) | AKR1C4AKR1C3AKR1C2AKR1C1MAPT | |
| SCHEMBL6811878 | 0.83 | CYP19A1 (0.59) | AKR1C4AKR1C3AKR1C2AKR1C1MAPT | |
| SCHEMBL11883066 | 0.82 | ALDH1A1 (0.63) | AKR1C4AKR1C3AKR1C2AKR1C1MAPT | |
| SCHEMBL7752953 | 0.82 | PIN1 (0.56) | AKR1C4AKR1C3AKR1C2AKR1C1MAPT | |
| SCHEMBL27346954 | 0.81 | MAPT (0.56) | AKR1C4AKR1C3AKR1C2AKR1C1MAPT | |
| SCHEMBL8578400 | 0.81 | MAPT (0.73) | AKR1C4AKR1C3AKR1C2AKR1C1MAPT | |
| SCHEMBL8569299 | 0.80 | MAPT (0.67) | MAPTLMNASMN1; SMN2POLBHTT | |
| SCHEMBL31541287 | 0.80 | MEN1 (0.52) | AKR1C4AKR1C3AKR1C2AKR1C1MAPT | |
| SCHEMBL11157919 | 0.80 | MEN1 (0.52) | AKR1C4AKR1C3AKR1C2AKR1C1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626373-B1 | Quinazolinone derivatives | SUMITOMO PHARMA (JP) | 1998-12-23 | — | — | EP | disclosed |
| US-5556860-A | ANTIISCHEMIC AGENTS, BRAIN DISORDERS AND BLOOD METAL CONCENTRATIONS AND KIDNEY DISEASE | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0626373-A1 | Quinazolinone derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-11-30 | — | — | EP | disclosed |
| US-3980645-A | Fused quinazolinones and a process for production thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-09-14 | — | — | US | disclosed |