Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 3/20 | 0.52 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.51 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8564200 | 0.85 | AGTR2 (0.49) | AGTR2AGTR1GP6 | |
| SCHEMBL8567814 | 0.84 | GP6 (0.65) | AGTR2AGTR1GP6 | |
| SCHEMBL9198036 | 0.79 | AGTR2 (0.58) | AGTR2AGTR1GP6 | |
| SCHEMBL8561087 | 0.76 | AGTR1 (0.64) | AGTR2AGTR1 | |
| SCHEMBL9003778 | 0.75 | AGTR2 (0.45) | AGTR2AGTR1GP6PPARG | |
| SCHEMBL4639206 | 0.74 | AGTR2 (0.55) | AGTR2AGTR1GP6 | |
| SCHEMBL8564639 | 0.73 | AGTR2 (0.67) | AGTR2AGTR1 | |
| SCHEMBL671 | 0.73 | PPARG (0.67) | PPARG | |
| SCHEMBL7359247 | 0.72 | AGTR2 (0.67) | AGTR2PPARG | |
| SCHEMBL8562299 | 0.71 | AGTR2 (0.55) | AGTR2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994001436-A1 | DIOXCYCLOBUTENE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS | THE BOOTS COMPANY PLC (GB) | 1994-01-20 | — | — | WO | claimed |
| EP-0649424-B1 | DIOXCYCLOBUTENE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS | KNOLL AG (DE) | 1998-10-07 | — | — | EP | disclosed |
| US-5627191-A | Therapeutic agents | THE BOOTS COMPANY PLC (GB) | 1997-05-06 | — | — | US | disclosed |
| EP-0649424-A1 | DIOXCYCLOBUTENE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS | Knoll AG (DE) | 1995-04-26 | — | — | EP | disclosed |
| WO-1994001436-A1 | DIOXCYCLOBUTENE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS | THE BOOTS COMPANY PLC (GB) | 1994-01-20 | — | — | WO | disclosed |