Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | ALPL | P05186 | 13/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15212089 | 0.86 | ALDH1A1 (0.76) | ALDH1A1TP53TDP1KMT2AALPL | |
| SCHEMBL31368924 | 0.83 | ALDH1A1 (1.00) | ALDH1A1TP53TDP1KMT2AALPL | |
| SCHEMBL3448568 | 0.83 | ALDH1A1 (1.00) | ALDH1A1TP53TDP1KMT2AALPL | |
| SCHEMBL644500 | 0.75 | ALPL (1.00) | ALDH1A1KMT2AALPLGAA | |
| SCHEMBL16509562 | 0.75 | ALPL (0.71) | ALDH1A1KMT2AALPLGAA | |
| SCHEMBL15220335 | 0.75 | ALPL (1.00) | ALDH1A1ALPLGAALMNA | |
| SCHEMBL1404359 | 0.75 | ALPL (1.00) | ALDH1A1ALPLGAALMNA | |
| SCHEMBL1050952 | 0.74 | MEN1 (0.66) | ALDH1A1TP53TDP1KMT2AALPL | |
| SCHEMBL29498554 | 0.73 | ALDH1A1 (0.65) | ALDH1A1TP53TDP1KMT2AALPL | |
| SCHEMBL13539338 | 0.73 | ALPL (1.00) | ALDH1A1ALPLGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433496-A1 | Tissue non-specific alkaline phosphatase inhibitors and uses thereof for treating vascular calcification | Burnham Institute for Medical Research (US) | 2012-03-28 | — | — | EP | disclosed |