Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 7/20 | 0.62 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569045 | 0.91 | GRIN2B (0.59) | GRIN2BOPRL1OPRM1OPRK1TSHR | |
| SCHEMBL8565348 | 0.89 | GRIN2B (0.53) | GRIN2BOPRL1OPRM1OPRK1TSHR | |
| SCHEMBL9727205 | 0.84 | GRIN2B (0.68) | GRIN2BOPRL1OPRM1OPRK1TSHR | |
| SCHEMBL8673995 | 0.84 | GRIN2B (0.68) | GRIN2BOPRL1OPRM1OPRK1TSHR | |
| SCHEMBL9947176 | 0.84 | GRIN2B (0.68) | GRIN2BOPRL1OPRM1OPRK1TSHR | |
| SCHEMBL9506641 | 0.82 | GRIN2B (0.66) | GRIN2BOPRL1OPRM1OPRK1TSHR | |
| SCHEMBL9018525 | 0.82 | GRIN2B (0.66) | GRIN2BOPRL1OPRM1OPRK1TSHR | |
| SCHEMBL7436031 | 0.82 | GRIN2B (0.66) | GRIN2BOPRL1OPRM1OPRK1TSHR | |
| SCHEMBL9947164 | 0.82 | GRIN2B (0.66) | GRIN2BOPRL1OPRM1OPRK1TSHR | |
| SCHEMBL9947167 | 0.81 | GRIN2B (0.64) | GRIN2BOPRL1OPRM1OPRK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0431943-B1 | Spiro(pyran)piperidine derivatives | MERCK & CO INC (US) | 1998-07-15 | — | — | EP | disclosed |
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0431943-A2 | Nitrogen-containing spirocycles | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |