Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.62 |
| ▸ | HTR1D | P28221 | 9/20 | 0.62 |
| ▸ | HTR1B | P28222 | 9/20 | 0.62 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR5A | P47898 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313298 | 0.83 | HTR1A (0.63) | HTR1AHTR1DHTR1BHTR3AHTR5A | |
| SCHEMBL6306922 | 0.81 | HTR5A (0.68) | HTR1AHTR1DHTR1BHTR3AHTR5A | |
| SCHEMBL3949525 | 0.81 | HTR1A (0.62) | HTR1AHTR1DHTR1BHTR3AHTR5A | |
| SCHEMBL6002177 | 0.80 | HTR1A (0.62) | HTR1AHTR1DHTR1BHTR3AHTR5A | |
| SCHEMBL7812700 | 0.80 | HTR1A (0.57) | HTR1AHTR1DHTR1BHTR5AMTNR1B | |
| SCHEMBL6000211 | 0.79 | HTR1A (0.75) | HTR1AHTR1DHTR1BHTR5ADRD2 | |
| SCHEMBL6305872 | 0.79 | HTR1A (0.59) | HTR1AHTR1DHTR1BHTR3AHTR5A | |
| SCHEMBL6001695 | 0.79 | HTR1A (0.63) | HTR1AHTR1DHTR1BHTR3AHTR5A | |
| Hydrochloric Acid SCHEMBL6306223 | 0.79 | HTR1A (0.56) | HTR1AHTR1DHTR1BHTR5AMTNR1B | |
| SCHEMBL7812213 | 0.79 | KDM4E (0.60) | HTR1AHTR1DHTR1BHTR5AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821245-A | Use of naphthalene derivatives in treating lung carcinoma | PFIZER INC. (US) | 1998-10-13 | — | — | US | disclosed |
| US-5789412-A | 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTOR ANTAGONISTS FOR THE CURATIVE OR PREVENTIVE TREATMENT OF PAIN, DEPRESSION, OBSESSIVE COMPULSIVE DISORDERS, ANXIETY OR PANIC ATTACK, OR CANCER | PIERRE FABRE MEDICAMENT (FR) | 1998-08-04 | — | — | US | disclosed |