Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PPIA | P62937 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560312 | 0.82 | GHSR (0.39) | GHSRCA1CA2HSD11B1 | |
| SCHEMBL8559137 | 0.82 | GHSR (0.39) | GHSRCA1CA2HSD11B1 | |
| SCHEMBL8580996 | 0.80 | GHSR (0.40) | GHSRAAK1CA12CA1CA2 | |
| SCHEMBL8560808 | 0.78 | SYK (0.35) | AAK1CA1CA2 | |
| SCHEMBL8569271 | 0.76 | GHSR (0.39) | GHSRCA1CA2HSD11B1 | |
| SCHEMBL8569372 | 0.72 | GHSR (0.39) | GHSRCA1CA2HSD11B1 | |
| SCHEMBL8576152 | 0.72 | GHSR (0.39) | GHSRCA1CA2HSD11B1 | |
| SCHEMBL8561322 | 0.71 | SYK (0.40) | GHSRCA12CA1CA2HSD11B1 | |
| SCHEMBL8997619 | 0.70 | GHSR (0.35) | GHSRCYP1A2 | |
| SCHEMBL8997625 | 0.70 | GHSR (0.37) | GHSRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640618-B1 | Tetrahydronaphthalene-peptide derivatives | HOFFMANN LA ROCHE (CH) | 1999-10-20 | — | — | EP | disclosed |
| EP-0729972-A1 | Peptide derivatives of tetrahydronaphthalene | F. HOFFMANN-LA ROCHE AG (CH) | 1996-09-04 | — | — | EP | disclosed |
| EP-0640618-A1 | Tetrahydronaphthalene-peptide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-03-01 | — | — | EP | disclosed |