Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8568719 | 0.89 | ALDH1A1 (0.49) | RAB9ANPC1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL2698893 | 0.87 | MEN1 (0.61) | RAB9ANPC1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL182622 | 0.83 | RAB9A (0.56) | RAB9ANPC1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL6983747 | 0.82 | ALDH1A1 (0.67) | RAB9ANPC1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8562291 | 0.81 | ALDH1A1 (0.55) | RAB9ANPC1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL11842385 | 0.81 | RAB9A (0.57) | RAB9ANPC1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5359165 | 0.80 | KMT2A (0.51) | RAB9ANPC1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL11380309 | 0.80 | KDM4E (0.63) | RAB9ANPC1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL12312149 | 0.80 | RAB9A (0.60) | RAB9ANPC1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7682008 | 0.80 | MAPT (0.55) | RAB9ANPC1MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |