Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8571284 | 0.88 | RAB9A (0.58) | KMT2AMEN1MAPTHTTLMNA | |
| SCHEMBL8569833 | 0.87 | HSD11B1 (0.48) | KMT2AMEN1HTR2AHTR2CHTR2B | |
| SCHEMBL7261534 | 0.87 | PDE4B (0.60) | KMT2AMEN1HTR2AHTR2CHTR2B | |
| SCHEMBL8571105 | 0.85 | HTR2A (0.55) | KMT2AMEN1HTR2AHTR2CHTR2B | |
| SCHEMBL14261447 | 0.85 | GAA (0.54) | KMT2AMEN1HTR2AHTR2CHTR2B | |
| SCHEMBL7267945 | 0.85 | KMT2A (0.53) | KMT2AMEN1HTR2AHTR2CHTR2B | |
| SCHEMBL7898046 | 0.85 | GAA (0.54) | KMT2AMEN1HTR2AHTR2CHTR2B | |
| SCHEMBL10772675 | 0.85 | GAA (0.54) | KMT2AMEN1HTR2AHTR2CHTR2B | |
| SCHEMBL7823697 | 0.85 | PDE4B (0.62) | KMT2AMEN1HTR2AHTR2CHTR2B | |
| SCHEMBL7267209 | 0.84 | MAPT (0.55) | KMT2AMEN1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739336-A | SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1998-04-14 | — | — | US | disclosed |
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |