Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569807 | 0.87 | KMT2A (0.53) | HSD11B1HDAC8KDM4EPOLBMAPT | |
| SCHEMBL8569681 | 0.82 | HTR2A (0.56) | HSD11B1HDAC8HDAC1KDM4EPOLB | |
| SCHEMBL8572525 | 0.80 | ALDH1A1 (0.56) | HDAC8HDAC1KDM4EPOLBMEN1 | |
| SCHEMBL8569591 | 0.80 | HDAC8 (0.67) | HDAC8HDAC1KMT2ALMNAHTT | |
| SCHEMBL8571105 | 0.79 | HTR2A (0.55) | POLBMAPTTSHRHTR2AHTR2C | |
| SCHEMBL8572013 | 0.78 | KDM4E (0.69) | HSD11B1KDM4EPOLBMAPTTTR | |
| SCHEMBL7261534 | 0.77 | PDE4B (0.60) | HSD11B1KDM4EMAPTTSHRCAPN1 | |
| SCHEMBL8567801 | 0.76 | KCNK3 (0.55) | KDM4EPOLBMAPTPPARGPPARA | |
| SCHEMBL8571284 | 0.76 | RAB9A (0.58) | HDAC1POLBMAPTMEN1KMT2A | |
| SCHEMBL7823697 | 0.76 | PDE4B (0.62) | HSD11B1KDM4EMAPTTSHRCAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739336-A | SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1998-04-14 | — | — | US | disclosed |
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |