Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 2/20 | 0.45 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CASP9 | P55211 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8418468 | 0.83 | ABCB1 (0.42) | LTB4RLTB4R2ABCB1ALDH1A1CASP3 | |
| SCHEMBL8599326 | 0.81 | LTB4R (0.69) | LTB4RLTB4R2ABCB1 | |
| SCHEMBL8570246 | 0.81 | LTB4R (0.69) | LTB4RLTB4R2ABCB1 | |
| SCHEMBL8418931 | 0.77 | LTB4R (0.50) | LTB4RLTB4R2ALDH1A1AKR1C3PPARG | |
| SCHEMBL8573087 | 0.77 | LTB4R (0.50) | LTB4RLTB4R2ALDH1A1AKR1C3PPARG | |
| SCHEMBL8560590 | 0.76 | TSHR (0.40) | ABCB1ALDH1A1AKR1C3PPARGKDM4E | |
| SCHEMBL8562961 | 0.74 | LTB4R (0.45) | LTB4RLTB4R2ALDH1A1KDM4EAPOBEC3A | |
| SCHEMBL8422487 | 0.74 | KDM4E (0.46) | ALDH1A1AKR1C3PPARGKDM4EAPP | |
| SCHEMBL8420123 | 0.73 | AKR1C3 (0.46) | LTB4RLTB4R2AKR1C3PPARGAPP | |
| SCHEMBL8420132 | 0.71 | PTGES (0.42) | LTB4RLTB4R2AKR1C3PPARGALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |