Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.74 |
| ▸ | HTR1A | P08908 | 7/20 | 0.74 |
| ▸ | HTR3E | A5X5Y0 | 7/20 | 0.65 |
| ▸ | HTR3B | O95264 | 7/20 | 0.65 |
| ▸ | HTR3A | P46098 | 7/20 | 0.65 |
| ▸ | HTR3D | Q70Z44 | 7/20 | 0.65 |
| ▸ | HTR3C | Q8WXA8 | 7/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878905 | 1.00 | HTR2C (0.74) | HTR2CHTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL8565965 | 0.87 | HTR1A (0.72) | HTR2CHTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL8565970 | 0.87 | HTR1A (0.72) | HTR2CHTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL8572090 | 0.83 | HTR2C (0.73) | HTR2CHTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL8563750 | 0.79 | HTR3E (1.00) | HTR2CHTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL8567791 | 0.77 | HTR3E (0.74) | HTR2CHTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL8563458 | 0.77 | HTR3E (0.73) | HTR2CHTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL8569563 | 0.75 | HTR3E (0.75) | HTR2CHTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL8569971 | 0.74 | HTR3E (0.73) | HTR2CHTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL2579539 | 0.73 | LMNA (0.72) | HTR2CHTR1ALMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623620-B1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR (FR) | 1998-09-09 | — | — | EP | disclosed |
| US-5599812-A | ANTISEROTONINE AGENTS | ADIR ET COMPAGNIE (FR) | 1997-02-04 | — | — | US | disclosed |
| EP-0623620-A1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR ET COMPAGNIE (FR) | 1994-11-09 | — | — | EP | disclosed |