Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | KDM5C | P41229 | 1/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8572643 | 0.81 | ALOX5 (0.58) | ALOX5MEN1KMT2ARIPK1GSK3B | |
| SCHEMBL6809052 | 0.81 | LTB4R (0.50) | ALOX5MEN1KMT2ARIPK1GSK3B | |
| SCHEMBL8573120 | 0.80 | ALOX5 (0.47) | ALOX5RIPK1GAAGSK3BPOLB | |
| SCHEMBL1176720 | 0.77 | LTB4R (0.56) | ALOX5RIPK1GSK3BPOLBALDH1A1 | |
| SCHEMBL5288668 | 0.74 | FFAR1 (0.51) | ALOX5RIPK1GSK3BHSD11B1ALDH1A1 | |
| SCHEMBL5481203 | 0.73 | ALDH1A1 (0.49) | ALOX5MEN1KMT2ARIPK1GSK3B | |
| SCHEMBL8352676 | 0.72 | USP2 (0.57) | MEN1KMT2APOLBALDH1A1KDM4E | |
| SCHEMBL8815622 | 0.71 | ALOX5 (0.44) | ALOX5MEN1KMT2ARIPK1GAA | |
| SCHEMBL6296480 | 0.70 | ALOX5 (0.45) | ALOX5MEN1KMT2ARIPK1GAA | |
| SCHEMBL6617196 | 0.70 | ALOX5 (0.43) | ALOX5MEN1KMT2ARIPK1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | claimed |
| US-5780473-A | Substituted biphenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-07-14 | — | — | US | claimed |
| US-5780473-A | Substituted biphenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-07-14 | — | — | US | disclosed |