Halcinonide

SCHEMBL8571550

CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)CC[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CCl)O1.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2C(=O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Halcinonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	8/20	0.65

▸	CYP3A4	P08684	6/20	0.65

▸	PGR	P06401	6/20	0.65

▸	AR	P10275	3/20	0.65

▸	USP2	O75604	1/20	0.65

▸	HIF1A	Q16665	8/20	0.54

▸	HSD17B10	Q99714	5/20	0.54

▸	SMN1; SMN2	Q16637	3/20	0.54

▸	SERPINA6	P08185	3/20	0.54

▸	CYP2C19	P33261	2/20	0.54

▸	SHBG	P04278	2/20	0.54

▸	NR3C2	P08235	1/20	0.54

▸	MAPT	P10636	1/20	0.54

▸	NFKB1	P19838	1/20	0.54

▸	KMT2A	Q03164	1/20	0.54

▸	LMNA	P02545	4/20	0.53

▸	CYP2D6	P10635	1/20	0.53

▸	TSHR	P16473	1/20	0.53

▸	ALDH1A1	P00352	1/20	0.53

▸	PMP22	Q01453	1/20	0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Halcinonide SCHEMBL8453347	0.95	NR3C1 (0.72)	NR3C1CYP3A4PGRARUSP2
Halcinonide SCHEMBL28149502	0.94	NR3C1 (0.71)	NR3C1CYP3A4PGRARUSP2
Halcinonide SCHEMBL10802060	0.90	NR3C1 (0.71)	NR3C1CYP3A4PGRARUSP2
Fluocinolone Acetonide SCHEMBL8451856	0.86	NR3C1 (0.60)	NR3C1CYP3A4PGRARUSP2
Fludrocortisone SCHEMBL3633796	0.83	NR3C1 (0.77)	NR3C1CYP3A4PGRARHIF1A
Halcinonide SCHEMBL28138594	0.82	NR3C1 (0.55)	NR3C1CYP3A4PGRARUSP2
Fludrocortisone SCHEMBL1333577	0.82	NR3C1 (0.80)	NR3C1CYP3A4PGRARHIF1A
Desonide SCHEMBL8649633	0.81	NR3C1 (0.69)	NR3C1CYP3A4PGRARUSP2
Halcinonide SCHEMBL24015431	0.81	NR3C1 (1.00)	NR3C1CYP3A4PGRARUSP2
Halcinonide SCHEMBL4336	0.81	NR3C1 (1.00)	NR3C1CYP3A4PGRARUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-1998006439-A1	POLYETHERESTER COPOLYMERS AS DRUG DELIVERY MATRICES	OSTEOTECH, INC. (US)	1998-02-19	—	—	WO	disclosed