Fluocinolone Acetonide

SCHEMBL8451856

CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)CC[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CCl)O1.CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO

nearest known ligand 0.60

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Fluocinolone Acetonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	9/20	0.60

▸	CYP3A4	P08684	6/20	0.60

▸	PGR	P06401	6/20	0.60

▸	AR	P10275	4/20	0.60

▸	USP2	O75604	1/20	0.60

▸	HIF1A	Q16665	9/20	0.59

▸	LMNA	P02545	5/20	0.59

▸	HSD17B10	Q99714	3/20	0.59

▸	MAPT	P10636	2/20	0.59

▸	TDP1	Q9NUW8	1/20	0.59

▸	KDM4E	B2RXH2	1/20	0.59

▸	MAPK1	P28482	1/20	0.59

▸	NR1I2	O75469	1/20	0.54

▸	SMN1; SMN2	Q16637	2/20	0.51

▸	ABCB11	O95342	1/20	0.51

▸	NPSR1	Q6W5P4	1/20	0.51

▸	KMT2A	Q03164	2/20	0.51

▸	ALDH1A1	P00352	1/20	0.51

▸	MEN1	O00255	1/20	0.51

▸	CYP2C19	P33261	2/20	0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Halcinonide SCHEMBL8453347	0.91	NR3C1 (0.72)	NR3C1CYP3A4PGRARUSP2
Halcinonide SCHEMBL28149502	0.91	NR3C1 (0.71)	NR3C1CYP3A4PGRARUSP2
Fluocinolone Acetonide SCHEMBL15568127	0.87	HIF1A (0.57)	NR3C1CYP3A4PGRARHIF1A
Halcinonide SCHEMBL8571550	0.86	NR3C1 (0.65)	NR3C1CYP3A4PGRARUSP2
Halcinonide SCHEMBL10802060	0.86	NR3C1 (0.71)	NR3C1CYP3A4PGRARUSP2
Fluocinonide SCHEMBL5664031	0.86	NR3C1 (0.62)	NR3C1CYP3A4PGRARUSP2
Halcinonide SCHEMBL9810174	0.85	CYP3A4 (0.68)	NR3C1CYP3A4PGRARUSP2
Fluocinonide SCHEMBL15568196	0.83	HIF1A (0.58)	NR3C1CYP3A4PGRARUSP2
Desonide SCHEMBL8649633	0.83	NR3C1 (0.69)	NR3C1CYP3A4PGRARUSP2
Fluocinonide SCHEMBL22463815	0.82	NR3C1 (0.75)	NR3C1CYP3A4PGRARUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0896541-A4	—	—	1999-03-24	—	—	EP	disclosed
EP-0896541-A1	SILVER-BASED PHARMACEUTICAL COMPOSITIONS	CAPELLI, Christopher C. (US)	1999-02-17	—	—	EP	disclosed
WO-1997002038-A1	SILVER-BASED PHARMACEUTICAL COMPOSITIONS	CAPELLI CHRISTOPHER C (US)	1997-01-23	—	—	WO	disclosed