SCHEMBL8573192

SCHEMBL8573192

O=C(Cl)c1nc2ccccc2c2ccccc12

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.52
ALDH1A1 P00352 2/20 0.52
MAPT P10636 1/20 0.52
KMT2A Q03164 2/20 0.46
GPR3 P46089 2/20 0.45
PDE10A Q9Y233 3/20 0.44
MAOA P21397 1/20 0.43
MAOB P27338 1/20 0.43
DYRK1A Q13627 2/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C19 P33261 1/20 0.42
HIF1A Q16665 1/20 0.42
HSD17B10 Q99714 1/20 0.42
KDM4E B2RXH2 4/20 0.42
GLA P06280 2/20 0.42
GAA P10253 1/20 0.42
HPGD P15428 1/20 0.42
ATM Q13315 1/20 0.42
CLK1 P49759 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28299251 0.83 ALDH1A1 (0.56) SMN1; SMN2ALDH1A1MAPTKMT2AGPR3
SCHEMBL3067398 0.83 ALDH1A1 (0.68) SMN1; SMN2ALDH1A1MAPTKMT2AGPR3
SCHEMBL28279288 0.80 MAP2K3 (0.53) SMN1; SMN2ALDH1A1MAPTGPR3MAOA
SCHEMBL28342069 0.76 KDM4E (0.54) SMN1; SMN2ALDH1A1MAPTKMT2AGPR3
SCHEMBL31026536 0.75 MAOA (0.52) SMN1; SMN2ALDH1A1MAPTKMT2APDE10A
SCHEMBL642681 0.75 MAOA (0.52) SMN1; SMN2ALDH1A1MAPTKMT2APDE10A
Hydrochloric Acid SCHEMBL5735696 0.73 PDE10A (0.50) SMN1; SMN2ALDH1A1MAPTKMT2APDE10A
SCHEMBL6992814 0.73 TDP1 (0.56) SMN1; SMN2ALDH1A1MAPTKMT2ADYRK1A
SCHEMBL6991670 0.73 ALDH1A1 (0.54) SMN1; SMN2ALDH1A1MAPTKMT2ADYRK1A
SCHEMBL6387026 0.72 MAPT (0.52) SMN1; SMN2ALDH1A1MAPTKMT2AGPR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5783699-A MAY BE CONJUGATED TO ANTIGENS, HAPTENS, ANTIBODIES IN IMMUNOASSAYS ABBOTT LABORATORIES (US) 1998-07-21 US disclosed
US-5669819-A IMMUNOASSAY ABBOTT LABORATORIES (US) 1997-09-23 US disclosed
US-5565570-A REACTING AMINE WITH SULFONYL HALIDE IN INERT SOLVENT IN PRESENCE OF BASE TO FORM METAL SALT OF SULFONAMIDE, ACYLATING WITH ACTIVATED PHENANTHRIDINE-6-CARBOXYLIC ACID TO FORM CHEMILUMINESCENT SALT ABBOTT LABORATORIES (US) 1996-10-15 US disclosed
US-5545739-A E.G., 5-METHYL-6-(N-2-CARBOXYETHYL-N=(2-CARBOXYETHYL)-PHENANTHRIDIN IUMCARBOXAMIDE CHLORIDE; IMMUNOASSAYS; STABILITY; SENSITIVITY ABBOTT LABORATORIES (US) 1996-08-13 US disclosed
US-5543524-A FORMING A SULFONAMIDE FROM AND AMINE AND A SULFONYL HALIDE AND AND ACYLATING WITH A CARBONYL HALIDE OF AN ACTIVATED ACRIDINE SALT ABBOTT LABORATORIES (US) 1996-08-06 US disclosed
US-5468646-A Chemiluminescent acridinium salts ABBOTT LABORATORIES (US) 1995-11-21 US disclosed
EP-0273115-B1 Chemiluminescent acridinium and phenanthridinium salts ABBOTT LAB (US) 1994-09-07 EP disclosed
EP-0273115-A2 Chemiluminescent acridinium and phenanthridinium salts ABBOTT LABORATORIES (US) 1988-07-06 EP disclosed