Hydrochloric Acid

Hydrochloric Acid

SCHEMBL5735696

Cl.O=C(Cl)c1c2ccccc2nc2ccccc12

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA known ✓ P21397 2/20 0.50
MAOB known ✓ P27338 1/20 0.50
GLA known ✓ P06280 4/20 0.47
GAA known ✓ P10253 2/20 0.47
CHRM2 known ✓ P08172 1/20 0.45
ADRA2A known ✓ P08913 1/20 0.45
CHRM1 known ✓ P11229 1/20 0.45
DRD1 known ✓ P21728 1/20 0.45
ACHE known ✓ P22303 1/20 0.45
SLC6A2 known ✓ P23975 1/20 0.45
ADRA1A known ✓ P35348 1/20 0.45
OPRM1 known ✓ P35372 1/20 0.45
KCNH2 known ✓ Q12809 1/20 0.45
PDE10A Q9Y233 3/20 0.50
RAB9A P51151 2/20 0.48
KDM4E B2RXH2 4/20 0.47
ALDH1A1 P00352 4/20 0.47
SMN1; SMN2 Q16637 4/20 0.47
DHODH Q02127 4/20 0.47
HPGD P15428 3/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL642681 0.98 MAOA (0.52) PDE10AMAOAMAOBRAB9AKDM4E
SCHEMBL31026536 0.98 MAOA (0.52) PDE10AMAOAMAOBRAB9AKDM4E
SCHEMBL7516228 0.92 PDE10A (0.56) PDE10AMAOAMAOBKDM4EGLA
Hydrochloric Acid SCHEMBL9597551 0.83 PDE10A (0.63) PDE10ARAB9AKDM4EGLAALDH1A1
Hydrochloric Acid SCHEMBL1603404 0.83 PDE10A (0.63) PDE10ARAB9AKDM4EGLAALDH1A1
SCHEMBL7534314 0.81 CDK4 (0.44) PDE10AMAOAMAOBKDM4EGLA
SCHEMBL29377848 0.80 PDE10A (0.66) PDE10AMAOAKDM4EGLAALDH1A1
SCHEMBL27550242 0.80 PDE10A (0.55) PDE10AMAOAMAOBRAB9AKDM4E
SCHEMBL641899 0.80 PDE10A (0.66) PDE10AMAOAKDM4EGLAALDH1A1
SCHEMBL20669570 0.80 PDE10A (0.75) PDE10AKDM4EALDH1A1SMN1; SMN2DHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111170994-B Preparation method of acridine inner salt 合肥华纳生物医药科技有限公司 2021-01-15 CN disclosed
CN-111170994-A Preparation method of acridine inner salt 合肥华纳生物医药科技有限公司 2020-05-19 CN disclosed
EP-0082636-B2 Luminescent labelling materials and procedures WELSH NAT SCHOOL OF MEDICINE (GB) 2006-10-18 EP disclosed
US-7122671-B1 Luminescent labelling materials and procedures UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) 2006-10-17 US disclosed
EP-0609885-B1 Acridinium compounds and conjugates thereof MOCHIDA PHARM CO LTD (JP) 2003-04-16 EP disclosed
EP-0754178-B1 NOVEL FUNCTIONALIZED HYDROPHILIC ACRIDINIUM ESTERS BAYER AG (US) 2003-01-15 EP disclosed
US-6414152-B1 COMPOUND CAPABLE OF UNDERGOING LIGHT EMITTING REACTION IN PRESENCE OF DILUTE SOLUTION OF SODIUM HYDROXIDE AND HYDROGEN PEROXIDE, COMPRISING ACRIDINIUM CARBONYL MOIETY SUBSTITUTED WITH ARYL MOIETY HAVING ATTACHED REACTIVE GROUP UNIVERSITY OF WALES COLLEGE OF MEDICINE OF HEATH PARK (GB) 2002-07-02 US disclosed
EP-0617288-B1 Long emission wavelength chemiluminescent compounds and their use in test assays NOVARTIS AG (CH) 2002-05-02 EP disclosed
US-6087502-A COMPOUNDS FOR MARKING ANTIGENS OR ANTIBODIES RECEPTOR BINDING ASSAY MOCHIDA PHARMACEUTICALS CO., LTD. (JP) 2000-07-11 US disclosed
EP-0982298-A1 Novel functionalized hydrophilic acridinium esters Ciba Corning Diagnostics Corp. (US) 2000-03-01 EP disclosed
EP-0273115-B1 Chemiluminescent acridinium and phenanthridinium salts ABBOTT LAB (US) 1994-09-07 EP disclosed
EP-0609885-A1 Acridinium compounds and conjugates thereof MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1994-08-10 EP disclosed
WO-1993020074-A1 HAPTENS, TRACERS, IMMUNOGENS AND ANTIBODIES FOR ACRIDINE-9-CARBOXYLIC ACIDS ABBOTT LABORATORIES (US) 1993-10-14 WO disclosed
US-5225584-A Phosphonate esters and trialkylsilyl phosphonate esters TROPIX, INC. (US) 1993-07-06 US disclosed
EP-0511366-A1 CHEMILUMINESCENT COMPOUNDS BECKMAN INSTRUMENTS, INC. (US) 1992-11-04 EP disclosed
WO-1992009580-A1 CHEMILUMINESCENT COMPOUNDS BECKMAN INSTRUMENTS, INC. (US) 1992-06-11 WO disclosed
US-4946958-A Chemiluminescent acridinium labelling compounds THE WELSH NATIONAL SCHOOL OF MEDICINE (GB) 1990-08-07 US disclosed
EP-0082636-B1 LUMINESCENT LABELLING MATERIALS AND PROCEDURES The Welsh National School of Medicine (GB) 1988-09-14 EP disclosed
EP-0273115-A2 Chemiluminescent acridinium and phenanthridinium salts ABBOTT LABORATORIES (US) 1988-07-06 EP disclosed
EP-0082636-A1 Luminescent labelling materials and procedures The Welsh National School of Medicine (GB) 1983-06-29 EP disclosed