SCHEMBL8574604

SCHEMBL8574604

CC(C)(C)OC(=O)NC(CC(=O)O)C(=O)NCc1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSS P25774 6/20 0.61
CTSK P43235 5/20 0.61
CTSB P07858 2/20 0.61
CTSL P07711 1/20 0.61
MMP8 P22894 1/20 0.56
BACE1 P56817 4/20 0.55
ATM Q13315 1/20 0.54
CCKBR P32239 1/20 0.54
AKT1 P31749 1/20 0.54
REN P00797 1/20 0.53
CA12 O43570 1/20 0.52
CA1 P00915 1/20 0.52
CA2 P00918 1/20 0.52
CA3 P07451 1/20 0.52
CA4 P22748 1/20 0.52
CA6 P23280 1/20 0.52
CA5A P35218 1/20 0.52
CA7 P43166 1/20 0.52
CACNA1C Q13936 1/20 0.52
SCN9A Q15858 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8574599 1.00 CTSS (0.61) CTSSCTSKCTSBCTSLMMP8
SCHEMBL23218021 0.90 CTSS (0.63) CTSSCTSKCTSBCTSLBACE1
SCHEMBL17614472 0.90 CTSS (0.63) CTSSCTSKCTSBCTSLBACE1
SCHEMBL23218022 0.90 CTSS (0.63) CTSSCTSKCTSBCTSLBACE1
SCHEMBL13583903 0.88 CTSS (0.62) CTSSCTSKCTSBCTSLMMP8
SCHEMBL9582823 0.88 CTSS (0.62) CTSSCTSKCTSBCTSLMMP8
SCHEMBL3383006 0.88 CTSS (0.77) CTSSCTSKCTSBCTSLATM
SCHEMBL30968897 0.88 CTSS (0.62) CTSSCTSKCTSBCTSLMMP8
SCHEMBL42634 0.88 CTSS (0.62) CTSSCTSKCTSBCTSLMMP8
SCHEMBL1290504 0.87 CA12 (0.70) CTSSCTSKCTSBCTSLBACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5763436-A ANTICOAGULANTS HOFFMANN-LA ROCHE INC. (US) 1998-06-09 US disclosed
US-5595999-A ANTICOAGULANTS HOFFMANN-LA ROCHE INC. (US) 1997-01-21 US disclosed
US-5583133-A ANTICOAGULANTS HOFFMANN-LA ROCHE INC. (US) 1996-12-10 US disclosed
US-5532232-A INHIBIT THROMBIN INDUCED PLATELET AGGREGATION; FIBRINOGEN ANTICOAGULANTS IN BLOOD HOFFMANN-LA ROCHE INC. (US) 1996-07-02 US disclosed
US-5393760-A Cardiovascular disorders, antitumor agents HOFFMANN-LA ROCHE INC. (US) 1995-02-28 US disclosed
US-5260307-A Inhibit thrombin-induced platlet aggregation and clotting of fibrogen in plasma HOFMANN-LA ROCHE INC. (US) 1993-11-09 US disclosed